Maria Angelica Linton
Angelica Linton joined Agouron Pharmaceuticals in 1993 as an Associate Research Scientist in the department of Medicinal Chemistry and has been involved in several projects, including Calcineurin (immunosuppressants), AICARFT (cancer), HIV protease, HCV Polymerase (antiviral), RAF (cancer) and most recently the AR project (cancer). She is now a Principal Scientist at Pfizer and has since gone on to contribute to several publications and key patents. She has also served as a Director of the Fujimoto Foundation, Japan, as a reviewer of applications of brilliant students with limited economic status in El Salvador in order to award scholarships.
Ms Linton became a licensed pharmacist in El Salvador upon completion of a 5-year program at Universidad Salvadorena Alberto Masferrer in 1988. She then held several positions at Ancalmo Pharmaceuticals in San Salvador as a Research and Development Scientist associate and as Production Manager Associate in the Liquid, Injectable and Cosmetic Pharmaceutical Departments. She had the opportunity to continue her studies at Rice University, earning a Masters degree in Organic Chemistry in 1993.
Key Areas of Research
I have participated in several therapeutic areas including oncology and antiviral diseases, participating on projects at various stages ranging from HTS triage, hit-to-lead all the way to late-stage clinical candidate selection. I have contributed to two candidate compounds, one which is being actively evaluated in clinic for HCV.
Professional Affiliations
American Chemical Society
Education
Rice University, Houston, Texas. M.A. in Chemistry Total synthesis of natural products, Prof. Marco Ciufolini Dissertation title: Photocycloaddition of Quinones to olefins: Mechanism and Applications. March, 1993. Universidad Salvadorena Alberto Masferrer (U.S.A.M), San Salvador, El Salvador B.A. in Chemistry-Pharmacy-Biology Summa Cum Laude, May, 1988.
Awards
Technical Achivement Award in Organic Chemistry (TAOC). American Chemical Society, 2009; National Award for excellence in Chemistry and Pharmacy. Association of Women Chemists and Pharmacists. San Salvador, 1988; Pharmedic Laboratories National Award in Chemistry. San Salvador, July, 1988; Honorary lieutenant of the Brazilian Air Force. San Salvador, October, 1986; U.S.A.M. Honor Award in Chemistry-Pharmacy-Biology 5 consecutive years. San Salvador, 1983-1987.
Published Articles
“Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors” Li, Hui; Tatlock, John; Linton, Angelica; Gonzalez, Javier; Borchardt, Allen; Dragovich, Peter; Jewell, Tanya; Prins, Tom; Zhou, Ru; Blazel, Julie; Parge, Hans; Love, Robert; Hickey, Michael; Doan, Chau; Shi, Stephanie; Duggal, Rohit; Lewis, Cristina; Fuhrman, Shella. Bioorganic & Medicinal Chemistry Letters 2006, 16(18), 4834-4838. Presentation: “Identification and Optimization of a Novel Non-Nucleoside Inhibitor of Hepatitis C NS5B Polymerase” Presented at the 6th biennial meeting HEPDART conference on Antiviral Research. Dec 11, 2005, Hawaii. “Design, synthesis and evaluation of novel 6-arylsulfonylamino-3-chloro-benzo[b]thiophene-2-carboxamides: Potent, lipophilic inhibitors of 5-aminoimidazole-4-carboxamide ribonucleotide transformylase” Tatlock J. H.; Linton, M. A.; Condon, B.; Davies, J. F., II; Escobar, J.; KFavorite Quote
Early bird gets the biggest worm.
En Espanol: "Al que madruga Dios le ayuda"
